Journal article
Risk-reducing salpingo-oophorectomy and breast cancer risk reduction in the gynecologic oncology group protocol-0199 (GOG-0199)
PL Mai, A Miller, MH Gail, S Skates, K Lu, ME Sherman, OB Ioffe, G Rodriguez, DE Cohn, J Boggess, T Rutherford, ND Kauff, JS Rader, KA Phillips, PA DiSilvestro, AB Olawaiye, MR Ridgway, MH Greene, M Piedmonte, JL Walker
Jnci Cancer Spectrum | OXFORD UNIV PRESS | Published : 2020
Abstract
Background: Risk-reducing salpingo-oophorectomy (RRSO) has been associated with approximately 50% breast cancer risk reduction among women with a pathogenic variant in BRCA1 or BRCA2 (BRCA1/2), a finding that has recently been questioned. Methods: We estimated incidence rates of breast cancer and all cancers combined during 5 years of follow-up among participants selecting RRSO or ovarian cancer screening (OCS) among women with a BRCA1/2 pathogenic variant or strong breast and/or ovarian cancer family history. Ovarian or fallopian tube or peritoneal cancer incidence rates were estimated for the OCS group. Breast cancer hazard ratios (HRs) for time-dependent RRSO were estimated using Cox regr..
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Grants
Awarded by National Cancer Institute
Awarded by NRG Oncology Operations grant
Awarded by NRG SDMC grant
Funding Acknowledgements
This study was supported by the Intramural (DCEG, CCR) and Extramural (DCTD/CTEP, DCP/CCOP) Research Programs of the National Cancer Institute. In addition, this study was supported by National Cancer Institute grants to the Gynecologic Oncology Group (GOG) Administrative Office and the GOG Tissue Bank (CA 27469) and to the GOG Statistical and Data Center (CA 37517) as well as NRG Oncology Operations grant number U10 CA180868 and NRG SDMC grant U10 CA180822. KAP is a National Breast Cancer Foundation of Australia Practitioner Fellow.